After ten years away, Mark Kane and his daughter, Eleanor, return home to New York City, hoping to find a cure for a rare affliction. Their neighbor Naomi Cole, an NYPD Homicide Detective, tries to balance investigating a brutal murder at work with raising her son Isaiah, whose newly sober father has suddenly come back into their lives. Claire Logan, a brilliant scientist, receives a devastating call from her estranged father, summoning her home.